Synthetic Biology Lab

School of Life Science, USTC


Welcome To Our Lab




We develop enable technologies for making synthetic DNA using parallel and miniaturized platform. We are interested in methods for making DNAs (and thus RNAs) as basic elelments/constructs for functional DNA/RNA clusters and proteins/protein comlexes, molecular devices of designed structures and functions, and synthetic biosystems. Genomes are extremely complex molecular machines, which contain essential information governing our lives. We have developed a novel solution photochemistry so that the regular nucleic acid chemistry are carried out for making DNA CHIPs that is used to read DNA sequences, probe DNA structures, and discover base variations/mutations. In a massively parallel fashion, these experiments are performed in parallel in a miniaturized setting. This is a new format of reaction and assay, involving high throughput combinatorial synthesis, biological sample processing, and bioinformatic computing. Our research projects include BIOCHIP-based DNA synthesis and synthetic DNA applications in RNA and protein synthesis, design and develop enzymatic systems for biosynthesis and metabolic reactions.


we are also interested in the metabolic engineering of thermo-tolerant microbes for the fast growth under elevatated temperature. Now we are focusing on the xylose assimilation of Yeast of K. marixius. The engineered K. marixainus constructed in our lab could produced xylitol and ethanol with very high productivity already. Further work will try to improve the tolerance of inhibitor in lignocellusic hydrosates.




MRSD: a web server for Metabolic Route Search and Design



School of Life Science

Associate Prof. Hong Jiong


Associate Prof. Wang Dongmei




Major subject areas

  1. Synthetic DNA engineering
  2. Protein design and protein engineering integration
  3. Metabolic Engineering


We were/are supported by:

  1. Four National Natural Science Foundation of China(31070028,31270149,31570082,31770085)
  2. National Basic Research Program of China (973) (2011CBA00801)
  3. National High Technology Research and Development Program (863)(2012AA02A708)
  4. Startup Fund from School of Life Science and Hefei National Laboratory for Physical Science at the Microscale
  5. Scientific Research Foundation for Returned Scholars, Ministry of Education of China
  6. Anhui Provincial Natural Science Foundation
  7. State Education Ministry and Specialized Research Fund for the Doctoral Program of Higher Education of China
  8. Fundamental Research Funds for the Central Universities  



Aug.18th, 2014 张佳获2014年中国微生物学会学术年会优秀学术论文交流奖


April. 25th 2014


Wan Wen and Li lulu's paper was accepted by Nucleic Acids Research



Jan. 26th 2014


Wang Rongliang 's paper was accepted by Biotechnology Progress



Oct. 29th 2013


Zhang Jia's paper was accepted by Bioresource Technol.


April. 25th 2013, Cougratulation!

Rongliang's paper was accepted by JIMB.



Jan. 8th 2013, Cougratulation!

Biao Zhang's paper was accepted by JIMB.


Jan. 27th 2012, Congratulation! Li LULU'S Xylitol Dehydrogenase paper was accepted by Molecular Biotechnology



Wan Wen got "Scholarship Award for Excellent Doctoral Student granted by USTC"



May 10th, 2011, Zhang Biao's Xylose reductase paper was accepted by JIMB. Congratulation!


May 6th, 2011, Wan Wen's CBM3 paper was accepted by AMB. Congratulation!


March 11st, 2011 祝贺汪荣亮投到Journal of Industrial Microbiology & Biotechnology的文章接收


· Nov.31st, 2010 李璐璐获2010年中国微生物学会学术年会优秀学术论文交流奖